The initial validation of Mousemet was carried out against von Frey filaments at the Comparative Biology Centre, Newcastle University and the data presented at the autumn meeting of the AVA in Liverpool 2011. The key findings were the following:
- The MouseMet data showed less variability than the filaments
- The operators observed that MouseMet was easier to use than the filaments
- Although the mean thresholds recorded with filaments were not significantly lower post-operatively, those recorded with MouseMet did show a significant decrease (although there was no significant analgesic effect).
Please Click here for a PDF of the poster from this study.
Following further development work to refine MouseMet further, two more validation studies were carried out at the Department of Medical Science, Bristol University. The immediate comment from the operator was that MouseMet was “faster and more comfortable to use” than the filaments. The results show that both the filaments and Mousemet measured a significant decrease in threshold post-operatively. The results were presented at an NC3Rs meeting in October 2012. Please Click here for this poster.
A validation study has also just been carried out at a University facility courtesy of the Medical Research Council. Results are also in press with the initial observation that MouseMet data shows less variability than the filament data and is quicker to use.
Finally, another university elsewhere in the world has now carried out a very successful validation of MouseMet. The results have been accepted for publication in “Pain”.